ea0090oc7.4 | Oral Communications 7: Pituitary and Neuroendocrinology 2 | ECE2023
Chasseloup Fanny
, Tosca Lucie
, Regazzo Daniela
, Proust Alexis
, Hage Mirella
, Kuhn Emmanuelle
, Jublanc Christel
, Mokhtari Karima
, Salenave Sylvie
, Gaillard Stephan
, Parker Fabrice
, Boch Anne-Laure
, Tachdjian Gerard
, Chanson Philippe
, Bouligand Jerome
, Occhi Gianluca
, Kamenicky Peter
Introduction: Paradoxical increase of GH following oral glucose load has been described in ~30% of patients with acromegaly and has been related to the ectopic expression of the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) in somatotropinomas. Recently, we identified germline pathogenic variants of lysine demethylase 1A (KDM1A) in patients with GIP-dependent primary bilateral macronodular adrenal hyperplasia with Cushings syndrome. Patients...